St. Louis Cardinals vs Pittsburgh Pirates Prediction, Odds & Preview — Sep. 22, 2026
St. Louis Cardinals visit the Pittsburgh Pirates on September 22, 2026.
Prediction Lab's stored Sharp Consensus currently gives St. Louis Cardinals a 60.0% win probability. That figure is a statistical model output for this matchup — not a guarantee, and not betting advice.
Game information
| Date | September 22, 2026 |
|---|---|
| Away | St. Louis Cardinals |
| Home | Pittsburgh Pirates |
Model moneyline
| Model | Side | Prob |
|---|---|---|
| Grinder2 | St. Louis Cardinals | 58.3% |
| Takedown | St. Louis Cardinals | 60.2% |
| Edge | Pittsburgh Pirates | 50.0% |
| XSharp | St. Louis Cardinals | 63.1% |
| Efficiency | Pittsburgh Pirates | 63.1% |
| Sharp Consensus | St. Louis Cardinals | 60.0% |
Sharp Consensus: St. Louis Cardinals (60.0%)
Markets & projections
| Prediction Lab proj | 3.5–4 |
|---|---|
| XSharp proj | 5.5–4.5 |
| PL total | 7.5 |
| XSharp total | 10 |
| XSharp run line | -1 |
| H2H | 7.3 combined runs over 3 meetings |
Why the models split
The stored models split on this moneyline. St. Louis Cardinals: Grinder2 (58.3%), Takedown (60.2%), XSharp (63.1%), Sharp Consensus (60.0%) Pittsburgh Pirates: Edge (50.0%), Efficiency (63.1%).
Sharp Consensus leans St. Louis Cardinals, while Edge, Efficiency lean the other way on the stored probabilities.
Available sportsbook moneyline on the stored board: St. Louis Cardinals +110, Pittsburgh Pirates -132. Compare that price with the model probability before treating either as a pick.
Takeaway
This preview is built from Prediction Lab's stored St. Louis Cardinals at Pittsburgh Pirates board for September 22, 2026. The current Sharp Consensus lean is St. Louis Cardinals at 60.0%. Use the MLB picks page for the live card, then check graded results after the game. Model probabilities can be wrong; they are not locks.
