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🏈 NFL AI Picks, Predictions and Model Probabilities

Our NFL picks are built using predictive systems that combine team performance metrics, quarterback play, and matchup data. We analyze offensive and defensive strengths to generate high-confidence predictions for spreads, totals, and moneyline outcomes.
Showing picks for 2026-09-27. View today's picks →
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📅 2026-09-27
🏈 NFL 1:00 PM ET
Los Angeles Chargers
Sharp Consensus
37.3%
Books Est. +230
Prediction Lab +158
@
Buffalo Bills
Sharp Consensus
62.7%
Books Est. -288
Prediction Lab -187
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Analysis ▾
Injuries
⚠ Chargers: T. Pipkins III (knee) — Injured Reserve ⚠ Chargers: K. Awosika (leg) — Out ⚠ Chargers: D. Tomlinson (hamstring) — Out ⚠ Chargers: E. Molden (hamstring) — Out ⚠ Chargers: B. Thompson (quadriceps) — Out ⚠ Chargers: D. Njoku (fibula) — Injured Reserve ⚠ Chargers: C. Kolar (forearm) — Out ⚠ Bills: J. Hancock (hamstring) — Injured Reserve ⚠ Bills: T.J. Sanders (appendix) — Out
🏈 NFL 1:00 PM ET
Carolina Panthers
Sharp Consensus
54.6%
Books Est. -151
Prediction Lab -131
@
Cleveland Browns
Sharp Consensus
45.4%
Books Est. +125
Prediction Lab +112
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Analysis ▾
Injuries
⚠ Panthers: C. Cherelus (shoulder) — Injured Reserve ⚠ Panthers: N. Scott (ribs) — Out ⚠ Panthers: D. Lloyd (calf) — Out ⚠ Panthers: J. Brooks — Injured Reserve ⚠ Browns: T. Jenkins (back) — Out
🏈 NFL 1:00 PM ET
New York Jets
Sharp Consensus
14.4%
Books Est. +214
Prediction Lab +568
@
Detroit Lions
Sharp Consensus
85.6%
Books Est. -265
Prediction Lab -811
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Analysis ▾
Injuries
⚠ Jets: K. Nwangwu (back) — Out ⚠ Jets: K. Mauigoa (quadriceps) — Out ⚠ Jets: M. Fitzpatrick (groin) — Out ⚠ Jets: M. Taylor (thumb) — Out ⚠ Jets: A. Smith (knee) — Injured Reserve ⚠ Jets: D. Onyemata (groin) — Injured Reserve ⚠ Jets: M. McCrary-Ball — Injured Reserve ⚠ Lions: T. Harper (ankle) — Injured Reserve ⚠ Lions: B. Bartch (foot) — Out ⚠ Lions: A. Maddox (foot) — Injured Reserve
🏈 NFL 1:00 PM ET
Houston Texans
Sharp Consensus
42.4%
Books Est. -132
Prediction Lab +127
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Indianapolis Colts
Sharp Consensus
57.6%
Books Est. +110
Prediction Lab -149
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Analysis ▾
Injuries
⚠ Texans: J. Hummel (groin) — Injured Reserve ⚠ Texans: E. Ingram (groin) — Out ⚠ Texans: J. Clowney (knee) — Out ⚠ Texans: N. Collins (hamstring) — Out ⚠ Texans: M.J. Stewart (quadriceps) — Out ⚠ Texans: H. To'oTo'o (shoulder) — Injured Reserve ⚠ Colts: A. Pierce (heel) — Injured Reserve ⚠ Colts: A. Dulin (ankle) — Out ⚠ Colts: M. Clemons (toe) — Injured Reserve
🏈 NFL 1:00 PM ET
Kansas City Chiefs
Sharp Consensus
62.2%
Books Est. -510
Prediction Lab -183
@
Miami Dolphins
Sharp Consensus
37.8%
Books Est. +378
Prediction Lab +154
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Analysis ▾
Injuries
⚠ Chiefs: C. McDonald (knee) — Injured Reserve ⚠ Dolphins: R. Beal Jr. (hamstring) — Out ⚠ Dolphins: J. Wright (foot) — Doubtful ⚠ Dolphins: C. Douglas (ankle) — Out ⚠ Dolphins: R. Harrison Jr. (hamstring) — Injured Reserve
🏈 NFL 1:00 PM ET
Tennessee Titans
Sharp Consensus
30.3%
Books Est. +125
Prediction Lab +217
@
New York Giants
Sharp Consensus
69.7%
Books Est. -151
Prediction Lab -263
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Analysis ▾
Injuries
⚠ Giants: J. Dart (knee) — Injured Reserve
🏈 NFL 1:00 PM ET
Cincinnati Bengals
Sharp Consensus
14.9%
Books Est. -172
Prediction Lab +545
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Pittsburgh Steelers
Sharp Consensus
85.1%
Books Est. +142
Prediction Lab -770
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Analysis ▾
Injuries
⚠ Bengals: A. Iosivas (thumb) — Injured Reserve ⚠ Bengals: B.J. Hill — Doubtful ⚠ Steelers: G. Dunker (knee) — Injured Reserve ⚠ Steelers: R. Dowdle (toe) — Out
🏈 NFL 1:00 PM ET
Seattle Seahawks
Sharp Consensus
84.5%
Books Est. -313
Prediction Lab -725
@
Washington Commanders
Sharp Consensus
15.5%
Books Est. +248
Prediction Lab +520
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Analysis ▾
Injuries
⚠ Seahawks: T. Okada (hamstring) — Out ⚠ Seahawks: J. Love (calf) — Out ⚠ Seahawks: Z. Charbonnet (knee) — Out ⚠ Seahawks: A. Bradford (knee) — Injured Reserve ⚠ Commanders: S. Cosmi (concussion) — Out ⚠ Commanders: F. Luvu (groin) — Out ⚠ Commanders: C. Okonkwo (hamstring) — Out ⚠ Commanders: J. Daniels (elbow) — Out ⚠ Commanders: N. Cross (internal injury) — Out
🏈 NFL 1:00 PM ET
New England Patriots
Sharp Consensus
44.7%
Books Est. +133
Prediction Lab +115
@
Jacksonville Jaguars
Sharp Consensus
55.3%
Books Est. -161
Prediction Lab -135
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Analysis ▾
Injuries
⚠ Patriots: Q. Hutchins (knee) — Injured Reserve ⚠ Patriots: D. Jones (shoulder) — Out ⚠ Patriots: D. Pettus (ankle) — Injured Reserve ⚠ Patriots: B. Schooler (back) — Out ⚠ Patriots: M. Onwenu (ankle) — Injured Reserve ⚠ Jaguars: A. Regis — Doubtful ⚠ Jaguars: B.J. Green II (elbow) — Injured Reserve
🏈 NFL 4:05 PM ET
Arizona Cardinals
Sharp Consensus
22.6%
Books Est. +291
Prediction Lab +325
@
San Francisco 49ers
Sharp Consensus
77.4%
Books Est. -374
Prediction Lab -413
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Analysis ▾
Injuries
⚠ Cardinals: D. Taylor-Demerson (back) — Out ⚠ Cardinals: W. Johnson (neck) — Injured Reserve ⚠ 49ers: D. Robinson (ankle) — Injured Reserve ⚠ 49ers: J. Thompson Jr. (ankle) — Out ⚠ 49ers: R. Height (hand) — Out ⚠ 49ers: N. Bosa (calf) — Out ⚠ 49ers: C.J. West (undisclosed) — Injured Reserve ⚠ 49ers: B. Aiyuk — Out
🏈 NFL 4:05 PM ET
Minnesota Vikings
Sharp Consensus
38.4%
Books Est. -132
Prediction Lab +150
@
Tampa Bay Buccaneers
Sharp Consensus
61.6%
Books Est. +110
Prediction Lab -178
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Analysis ▾
Injuries
⚠ Vikings: N. Samac (knee) — Injured Reserve ⚠ Vikings: B. Thorson (hamstring) — Out ⚠ Buccaneers: J. Trotter (shoulder) — Out ⚠ Buccaneers: R. Bain Jr. (groin) — Out ⚠ Buccaneers: J. Hayes — Injured Reserve
🏈 NFL 4:25 PM ET
Baltimore Ravens
Sharp Consensus
73.9%
Books Est. -161
Prediction Lab -332
@
Dallas Cowboys
Sharp Consensus
26.1%
Books Est. +133
Prediction Lab +268
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Analysis ▾
Injuries
⚠ Ravens: R. Stanley (toe) — Out ⚠ Ravens: T.J. Tampa (knee) — Injured Reserve ⚠ Cowboys: P.J. Locke (foot) — Injured Reserve ⚠ Cowboys: C. Durant (hamstring) — Out ⚠ Cowboys: M. Hooker (forearm) — Out ⚠ Cowboys: D. Overshown (hamstring) — Out
🏈 NFL 4:25 PM ET
Las Vegas Raiders
Sharp Consensus
34.3%
Books Est. +133
Prediction Lab +180
@
New Orleans Saints
Sharp Consensus
65.7%
Books Est. -161
Prediction Lab -216
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Analysis ▾
Injuries
⚠ Raiders: A. O'Connell (personal) — Out ⚠ Raiders: T. Stukes (concussion) — Out ⚠ Saints: K. Banks Jr. (ankle) — Injured Reserve ⚠ Saints: C. Miller (toe) — Out ⚠ Saints: B. Brown (hamstring) — Out
🏈 NFL 8:20 PM ET
Los Angeles Rams
Sharp Consensus
38.1%
Books Est. -151
Prediction Lab +152
@
Denver Broncos
Sharp Consensus
61.9%
Books Est. +125
Prediction Lab -181
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Analysis ▾
Injuries
⚠ Rams: K. Kinchens (hamstring) — Doubtful ⚠ Rams: P. Nacua (hip) — Doubtful ⚠ Rams: R. Rivers (calf) — Injured Reserve ⚠ Broncos: J. Coleman (ankle) — Injured Reserve ⚠ Broncos: J. Cooper (Colo.) — Out ⚠ Broncos: N. Gargiulo (knee) — Out
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